The Arsenal duo of captain Martin Odegaard and Riccardo Calafiori, have not been spotted with the rest of the team that arrived at the Tottenham Hotspur Stadium for Sunday’s North London derby.
Both players picked up ankle injuries and were doubts for the Premier League fixture.
Gunners boss, Mikel Arteta, has now decided to leave them out of the squad.
Arteta made three changes to the side that started the 1-1 draw with Brighton before the international break.
Gabriel Martinelli and Jorginho come into the starting XI, with Raheem Sterling and Gabriel Jesus named on the bench.
Tottenham vs Arsenal: Odegaard, Calafiori missing from Arteta’s squad for EPL clash